Windows Defender Blocking items-should I unblock them?

[bob clere]

Windows Defender has blocked the following items from running on start-up.
Does anybody know if this is a legitimate block, or should I unblock them?

> shellopencmd:
> hkcu@s-1-5-21-4243344806-1414924530-875055578-1001\software\classes\wow6432node\mailto\shell\open\command\\
>
> shellopencmd:
> hkcu@s-1-5-21-4243344806-1414924530-875055578-1001\software\classes\mailto\shell\open\command\\
>
> file
> c:\program files (x86)\Microsoft office\office12\outlook.exe
>
> Anybody know if this is legitimate?
> Thanks
>